This chapter presents a brief overview of neoplasia in invertebrates and available resources; however, it is not an exhaustive literature review on neoplasia in the invertebrates. Neoplasia is the uncontrolled proliferation of cells due to genetic alterations that cause a failure to respond to normal regulatory signals. Tumor registries for humans and mammals had been established to provide similar information and were instrumental in advancing the study of neoplasia. Since the earliest reports of anomalous growth in hard corals, the question of whether such lesions represent true neoplasms has been debated. Gonadal tumors, the second most commonly identified tumor in bivalves, usually termed germinomas, are seen in many species of bivalves and are characterized by replacement of normal gonadal tubular architecture by a monomorphic population of round to oval neoplastic cells that fill the tubules. External lesions, particularly papilliform tumors of the body wall and carapace, could be amenable to surgical excision.
Newton, A., Smolowitz, R., Reynolds, T., & Peters, E. (2021). Neoplasia. Invertebrate Medicine, 631-644. https://doi.org/10.1002/9781119569831.ch26