Title

Approaches to identify, clone, and express symbiont bioactive metabolite genes

Document Type

Article

Comments

Published in: Natural Products Reports, vol.21, issue 1, 2004.

Abstract

This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

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