"Investigation of the Permeability of Antiretroviral Drugs Lamivudine a" by Senem Şanlı, Mustafa Sinan Kaynak et al.
 

Investigation of the Permeability of Antiretroviral Drugs Lamivudine and Valganciclovir via Single-Pass Intestinal Perfusion (SPIP) Method

Document Type

Article

Publication Title

Current Pharmaceutical Analysis

Publication Date

1-1-2024

Abstract

Introduction: Antiretroviral medications are widely used to treat HIV infections. Lamivudine (3TC) is prescribed for HIV-1 infection management in adults and pediatrics, while valganciclovir (VGC) is a prodrug of ganciclovir derived from valine. Methods: The Biopharmaceutics Classification System (BCS) estimates the contributions of intestinal permeability, dissolution, and solubility in oral drug absorption. Intestinal permeability refers to a substance's capacity to pass through the protective layer of cells in the intestine. The intestinal permeability of 3TC and VGC was analyzed and categorized using the single-pass intestinal perfusion technique according to the BCS in male Sprague Dawley rats, and a reversed-phase HPLC method was validated for precise and accurate measurement. Results: According to the BCS, 3TC and VGC have been classified as having low permeability when compared to metoprolol tartrate, which is classified as Class I with good permeability and resolution. Conclusion: The permeability values derived from this work can be valuable in exposure assessment models.

Volume

20

Issue

7

First Page

585

Last Page

596

DOI

10.2174/0115734129310868240805065851

ISSN

15734129

E-ISSN

1875676X

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